The "No, seriously This is the Final Boss for reals this time" Repentance guide for peoples. Having a higher movement speed allows you to kick it harder, Enemies hit by the cube while moving have a high chance to become frozen. Using Sumptorium as her will then cause all Clots to be consumed and return your hearts back to you. Cursed gives a card that buys everything in a shop for free (or devil room) Waka Waka and the Host unlock some great items (scythe tears, and added laser to your tears without harming normal tears) Family Man unlocks epic fetus, which is way overpowered. UNLOCK: Unlock this card by opening Mom's Box on the Home floor. It will attempt to hide behind you when shooting. the lost item pool, white, blue, cross, jar, Gives Isaac an eternal heart and the ability to fly, UNLOCK: Unlock this item by beating the Chest with Blue Baby, * golden chest pool, gold chest pool, blue head, the lost item pool, dead, ball, Upon taking damage, Isaac will fart a few times, causing all enemies in close proximity to become poisoned and leaving a gas cloud behind, Black Bean deals your tear damage for 6 ticks, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, item room, treasure room, item room pool, the lost item pool, kidney, grey, gray, Allows Isaac to fly while the White Pony is held, While held, sets your speed stat to 1.5 if it isn't already that high. Following the path takes you to an abandoned mineshaft, which leads you to a pedestal with the Knife Piece. UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted Bethany, Spawns a random pedestal item from the current room's item pool, In exchange, turns one heart container or 2 soul hearts into a broken heart. They also retain most of your bomb synergizing items, This item causes your bombs to stick to enemies and when exploding will leave white creep on the ground which slows enemies, When one of your bombs kills an enemy, a bunch of blue spiders are spawned to fight by your side, which deal x2 your current damage, Item Pool: Item Room, Greed Mode Item Room, Bomb Beggar, Bomb Beggar, Shooting in one direction increases your fire rate until a cap is reached, The maximum effect is to halve your delay, which takes roughly 10 seconds to achieve, The accuracy of your tears is also reduced as your fire rate increases, As soon as you change firing direction, your fire rate is reset to its normal amount, Tears will now travel through walls and appear out of the opposite wall, similar to a portal-type mechanic, Your tears can now also travel over rocks and objects in the environment, Spawns 3 random types of hearts on the floor, *, pink, blonde, yellow, red, bow, baby mr dolly, Causes Isaac to spawn 6 troll bombs on the floor every time he gets hit, similar to the Anarchist Cookbook mechanic, Doesn't trigger on damage taken from blood donation machines and devil beggars (but still triggers on other forms of intentional self damage such as IV Bag), Item Pool: Item Room, Red Chest, Curse Room, Greed Mode Item Room, *, blue, orange, poster, torn, paper, page, ripped, A familiar baby that has a random chance to drop a battery pickup or freeze all enemies in the room for a short while, Charged Baby also has a chance to add one charge to your spacebar item, These effects can only occur while in a hostile room with enemies, Gives Isaac a +25% damage up for every tear that successfully hits an enemy, The bonus from Dead Eye maxes out at double your damage (+100%), If a tear misses an enemy, there is a chance for the multiplier to be reset back to 1. After killing a 15 enemies, Blood Puppy transforms into an aggressive version that will also attack Isaac by charging at him. Beat the boss and move on to Corpse II to finally take on Mother. UNLOCK: Unlock this item by defeating Isaac as Jacob & Esau. White poop Dips have a small Hallowed Ground aura effect, increasing your damage and fire rate while standing in it. If the heart is hit, Isaac will take damage, Most enemies will target the heart over Isaac himself, Blood donation machines and devil beggars can be used for free. Isaac takes a full heart if hurt by Blood Puppy and it drops a full red heart for every 10 enemies it kills. Creator Edmund McMillen called it the "best version of Isaac". Frozen enemies never unfreeze and are considered dead by the game. I think the game was actually too easy before. Tears are now white, do a lot more damage and move slower across the screen with a homing effect, * angel room pool, god room pool, angel room item, red, fire, flame, orange, cross, Does not increase your damage, simply makes your tears red, * boss room pool, boss room item, sticks, brown, yellow, * angel room pool, god room pool, angel room item, the lost item pool, cup, wooden, gold, Based on the Steam Workshop mod created by Scayze and Ashkait, *, eyes, eyeball, bloody, white, red, googly googley, bank shot, Upon entering a room, a skull appears over a random enemy's head, Killing the marked enemy will cause the skull to move to a different enemy, If all enemies in the room are cleared in the order they are marked, Isaac gains a random reward from one of the following: Soul heart, Key, Pill, Bomb, Nickel, +0.2 Speed, +0.5 Range, +0.5 Tears, +1 Flat damage or +1 luck, Killing enemies in the wrong order will end the streak and deny you any extra rewards, Added as part of the Afterbirth+ Booster Pack #4. Stat Down becomes Stat Up. Neptunus: Permanently gives Isaac its massive tear rate with no charge. Teratoma, Envy) then Meat Cleaver will deal a lot of damage and trigger the splitting effect, If the split enemy has low enough health, it will just die instead of splitting, Doesn't work on end-game bosses except Delirium, where it will deal a chunk of damage and spawn a 2nd Delirium to deal with, UNLOCK: Unlock this item by defeating Mother in the Corpse II as Isaac, You no longer take damage from poison/toxic gas/burn effects, and become immune to fear/confusion, This item isn't available in any item pools - you are automatically given it after defeating Dogma, just before The Beast sequence, Grants a one-time use of the Holy Mantle effect, On normal mode this grants The Wafer effect, causing all damage to do a maximum of half a heart each time, Sets your health to 6 hearts if you have fewer than 6. Basement 1, Cathedral, Sheol etc. He can pick up coins to restore health, Similar to other familiars of this kind, you can hold the drop key to cause him to stand still, If he dies, his corpse turns into a few blue spiders. This one will be a hidden question mark, Allows you to see what both items are on alternative path floors (Downpour/Dross, Mines/Ashpit, Gehenna/Mausoleum), UNLOCK: Unlock this trinket by defeating challenge #40 (Seeing Double). You can pick which dice you want to use. Possible doors include any needing a key to open (Item Room, Shop, Alt Path doors), secret rooms and crawl spaces, Cracked Orb can also reveal the location of the red room that contains a pedestal item. Also summons a blue crosshair which can be moved around freely. Counts as 1 of 3 mushroom items needed towards the Fun Guy transformation. Gives Isaac a little portal familiar, that moves across the screen as you're firing, The portal will suck up any consumables and trinkets it travels over, causing it to become larger and deal more contact damage, When the portal sucks up 4 pickups, it turns into a portal that can be used to teleport to unexplored rooms around the floor. Doesn't apply to progress items like The Polaroid, When you pick up an item that increases your maximum HP, you gain 2 permanent stat increases, and a temporary damage boost that slowly goes down over time. poop, pots), Counts as 1 of 3 cat items needed towards the Guppy transformation, UNLOCK: Unlock this item by defeating Mother in the Corpse II as Cain, Item Pool: Devil Room, Curse Room, Red Chest, Spawns a Keeper familiar, that shoots triple tears and follows your exact movements as you walk, The keeper has 3 health coins and can die if it takes enough damage. Function: Gives Flight, +2 Soul Hearts, Holding down the fire button for 2.35 seconds charges a beam that deals 15 ticks of your tear damage, Unlock Condition: Defeat Mother as Bethany. Function: Every item pedestal cycles through 5 different options really fast, Unlock Condition: Defeat the Beast as Tainted Isaac. Unlocked from Challenge #24 - PAY TO PLAY, Power Pill - Gives you invulnerability and the ability to damage enemies for a short while (similar to The Gamekid effect), Re-Lax - Causes Isaac to spawn poops behind him while he walks for a few seconds. Also the hit detection has been improved - Technology fires in a straight line, * item room, treasure room, item room pool, silver, gray, grey, red, machine, Tears Down significantly (Tear delay * 2.1 + 3), Synergizes well with a lot of tear effects - e.g. ?s only friend, blue bozzy, An iron ball and chain attached to Isaac, similar to Guppy's Hairball that you can fling around to deal 5 damage per tick, The ball will block enemy shots and can also destroy environmental objects such as rocks, mushrooms and skulls, Does not decrease your movement speed stat at all however the ball has to be dragged around causing Isaac to slow down slightly when the chain is fully extended, UNLOCK: Unlock this item by beating Boss Rush with Samson, * secret room pool, item room, treasure room, item room pool, grey, gray, shackle, A familiar that will follow Isaac and copy the effect of one of your other familiars, If you don't have any other familiars, he will just shoot normal tears, REPENTANCE - Removed the double damage multiplier on Mongo Baby's attacks, * item room, treasure room, item room pool, pink, blue, grey, gray, An active item that fires 8 of Isaac's tears in a circle around him, Tears spawned from this item keep most effect that Isaac currently has applied to his tears, and deal an additional +5 flat damage, UNLOCK: Unlock this item by beating the Isaac boss with Isaac, * item room, treasure room, item room pool, glass, blue, water, isaacs tears, Upon use, teleports you to one of the following rooms at random: Item room, Secret room, Super secret room, the I AM ERROR room or the Black Market (very low chance), There are no I AM ERROR rooms on the final floors, preventing looping with this item, UNLOCK: Unlock this item by beating Boss Rush with Eden, * item room, treasure room, item room pool, pink, purple, red, broken, When used will cut your head from your body. black, white, gray, grey, guppys tail, guppy tail, Upon use, the IV Bag takes half a red heart and spawns 1-3 coins (the same effect as a blood donation machine), Can drop from a blood donation machine after playing it, In the Womb and beyond this deals 1 full heart of damage, If no red hearts exist, other types of hearts are consumed instead, With the Keeper this is changed to spawning 0-1 coins per use instead, Item Pool: None (Blood donation machine only), Places a decoy on the floor which attracts enemies and explodes after a period of time, When it explodes, it deals 185 damage to everything in radius (Same damage as Mr Mega bombs), * item room, treasure room, item room pool, worst friend, dead, baby, pink, puppet, Bombs no longer automatically explode and will only do so when you activate the remote detonator, Can be used to detonate Dr. Fetus bombs early, * boss rush pool, boss rush room, shop room pool, shop item pool, item room, treasure room, Frozen enemies can be pushed into obstacles where they shatter on contact and fire ice shards around them. Maggy - +1 HP up. It leaps at enemies, dealing contact damage and firing quad shots at them for the rest of the room. Pills with effects that can't necessarily 'double' are stronger, i.e. You still take damage however when using Blood Donation machines and Devil Beggars, *, spikes, spikey, spike rock, greyhost, grey host, Causes all pedestal items to show up as rotating items, that swap every 1 second between the original spawned item and a HP up item. #9 Black May 23, 2021 @ 11:46am Originally posted by Squaredudes: They do not block enemy shots, UNLOCK: Unlock this item by defeating The Beast as Tainted Lilith, Isaac builds rage each time you clear a new room. Devil Rooms / I AM ERROR rooms, UNLOCK: Unlock this item by defeating Mother as Apollyon, You gain a familiar that lives under the floor. If you have PhD it will only increase one stat, Can be used multiple times, but every time you use it, it has a chance to disappear, The Gold Pill can spawn as a Horse Pill, which then causes it to give random Horse pill effects, UNLOCK: Unlock this by defeating Mega Satan as Tainted Cain, Horse Pills rarely spawn as larger versions of normal pills with more powerful effects, Items that synergize with pills also have the same effect with Horse pills, In general, the effect of a Horse Pill is double the effect of a normal pill i.e. Holding the fire button charges a spin attack (Damage * 8 + 10). The Binding of Isaac: Repentance is the latest expansion for the iconic roguelike, and to say it brings some seismic changes is an understatement. You get a couple of seconds of invincibility to move away after, The main benefit of this Soul Stone is that it automatically activates if you die, meaning it is effectively an extra passive life while held, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Lazarus, Activates the D6 and D20 effects, rerolling all items and pickups in the room. The effect is weaker than normal runes. UNLOCK: Unlock this item by defeating Lil Horn 20 times, When picked up, gives Isaac a random familiar which has a random sprite and tear effect, The familiar will be fully randomized again upon entering the next floor, The appearance is chosen from a random co-op baby sprite, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Ashkait and Scayze, A familiar that will transform into another random familiar every 10 seconds, copying their behaviour and effect, Can be any other familiar, including (but not limited to) Lil Brimstone, Bob's Brain, BBF, Meatboy, Rotten Baby, Familiars appear as a white Delirium version of the original, This item gives you 1 bar of charge on your active item for every 15 enemies you kill, Added as part of the Afterbirth+ Booster Pack #2 and based on the Steam Workshop mod created by Ashkait and Scayze, UNLOCK: Unlock this item by picking up any 3 of these items in a single run: 9 Volt, The Battery, Car Battery, AAA Battery, Watch Battery, When used, the coupon causes one random item in the shop to become free, While held, guarantees a random item or pickup from the shop to be half price, The effect of this item also works in Devil Rooms, allowing you to take one random item for free, Added as part of the Afterbirth+ Booster Pack #2 and based on the Steam Workshop mod created by Plumbo, *, paper, square, green, pink, white, barcode, letter, postcard, An active that causes all enemy tears to be held in place and then thrown back away from Isaac for a period of 3 seconds, The aura from this item will repel nearby enemies, Added as part of the Afterbirth+ Booster Pack #2, When used, the box will pick up a maximum of 6 items. Everything is sold for its shop price, e.g. Dead Bird) then Box of Friends will cause it to spawn but won't create duplicates, This can be used multiple times in the same room to generate more familiars, meaning you can get a level 4 meatboy or bandage girl by using this item 3 times in the same room, If used when you have no familiars, it will give you a Demon Baby temporarily, UNLOCK: Unlock this item by beating Greed Mode with Lilith, Isaac wears a dunce hat and fires 2 tears at once diagonally, similar to the R U A WIZARD pill tear pattern, * Item Room, Greed Mode Item Room, dunce cap, white, hat, cone, Replaces Isaac's tears with nails, which have increased knockback, The increased knockback will also affect Brimstone, which usually has no knockback at all, Gives you a familiar demon incubus that follows you and shoots tears that scale with your own tears in terms of damage, stats and also effects, It will mimic any tear effects you currently have and also copy your current stats, meaning it will fire with the same damage, fire rate and range, Incubus' damage is reduced by 25% when playing as characters other than Lilith, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Lilith, Item Pool: Devil Room, Greed Mode Devil Room, A familiar blue head that will follow Isaac and fire tears copying his tear damage and effects, This familiar is very similar to Incubus, however it only copies damage and is not affected by tears or range upgrades, UNLOCK: Unlock this item by beating Blue Womb (Hush) with ??? + 10 ) too easy before it the & quot ; best version of Isaac quot! 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