After about 2.5 weeks, she couldn't walk, bark, had tremors, didn't want to eat, and was so lethargic I thought we were going to lose her. Two quick questionsDo the dogs eventually return to normal? Parasite prevention is not only important for your dog's healthit also protects the people around your dog. I will post an update 7 days later. She still has her appetite at the moment. At the vet today, I bought a single dose of Simparica Trio to try instead of Trifexis and Combogaurd, because they seem less tolerated by her now that she is older. Im convinced it was caused by this drug. I began researching this today as the same thing seems to be happening to my Havanese mix since starting this several months ago. She has episodes where she seems very anxious and is hiding under car/tables/beds. He has been on simparica since he was old enough to take it. Does your do still have a cough? I failed Bentlee this past week and changed to Simparico Trio and now he is having all the same kind of issues. . She was shaking like she was freezing. Can you tell me if your dog is back to normal now?!?! How is your puppy now after 7 months leases our 2 yr old frenchie just spent 3 days hospitalized and clearly has neurological symptoms. He doesn't seem to be throwing up as much anymore, he did several times throughout the night though. I have 3 other dogs - large breeds that also took 1 dose, but no reaction. Simparica trio is a de-worming medication. The site is secure. In general dogs tolerate very well sarolaner at the therapeutic dose range (2 to 4 mg/kg). As I said, the first was a week after taking it, then the 2nd and third seizure happened at day 29. We are now at about 45 days since last simparica and he is back to his old self. I will be discontinuing the medication. She had the treatment yesterday and seemed ok. Does anyone know of anything we can give her to help get this out of her system? Hope all is well .my dog is 3,ive had him on Simparica trio for about 1.5 years and have noticed belly weight gain ,constant itching and some lethargy.his tounge hangs out of his mouth constantly which never happened prior to the medication .i have told my vet about these symptoms but they are quick to suggest its not related to the Simparica even though this all came about after putting my pet on this treatment.I decided last month to go against my vets recommendation and take my pet off the drug .maybe i put to much trust ij my vet and shouldve taken my dog off this drug sooner .better late then never .anyone suggest a tick and flea treatment less harmful for dogs ?? Seems like it was directly related to the medication. my puppy was prescribed this and now is weeing more often than usual and still itching ! Something I will never know what happened to herIf I knew this would kill her I would never had used it. We are now 2-3 weeks after our dog's dose of Simparica and are hoping for some improvement in her neurological symptoms as time goes on. I also am seeking information as to if there is a class action suit against this company because there should be. Im beside myself with guilt and fear. The ONLY thing that could cause such a huge change in behavior and personality had to be giving him the Simparico Trio the previous week. And how long for this sheet to get out of the dogs system??? She had a marked alteration in balance, lost her ability to navigate stairs, and lost all vocalization for almost 4 weeks. This medicine needs to be stopped. Possible side effects: Vomiting, diarrhea (if these . The FDA considers this level to be "very rare". We contacted the company using the phone number supplied in the under in the box and shared our experience with the new drug. She is now 2 1/2 months post event. I took him to the ER they checked his vitals and sent me home. Started giving my dogs Simparica Trio 5 months ago didn't put together the changes in the one dogs personality until today within a couple of weeks she would all of a sudden go from a loving dog to attacking the other dog it is getting worse. He will be laying then start shaking all over..Has tremors every 5 minutes for 2 hours now. She has been diagnosed with thyroid problems and myocarditis. My vet never mentioned that puppies under 6months cannot be prescribed this medication. I am a new dog owner, gave my 14 weeks old german shepherd the 1st Simparica trio pill yesterday morning 8 am, she starts to vomit around 5 pm, having more frequent uranating, and loose poop, this continued until 8 pm when she's tired and finally slept. Hi, how long it took for the diarrhea to go away. After seeing his condition worsen, that night we took him to an after hours urgent care. Meaning he is suppose to get it today. Pyrantel Pamoate was first approved in 1977 for the treatment and . She nearly died. I to also gave my best friend Simparica as recommended by the vet. I hope we get to the bottom of it as this is not fun. I should have kept with my gut feeling about any of these oral meds. He collapsed & went limp in my arms . Any other alternatives that are not harmful? Company asked us to do diagnostic testing at vet. No simparica for them either! I would say these changes may have happened more suddenly than just normal aging so I'm not going to give him this medication anymore. Im convinced the medicine caused this and now she cant walk. he didn't throw up but he doesn't want to go to bed at night and he just paces around the bedroom and sometimes goes under the bed. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). It has been 20 days since I gave her the prescribed dose of Simparica. Needless, to say I will not be giving them the simparica trio again. Other signs may include: Contact your veterinarian if you notice these or other signs of illness after giving Simparica Trio to your dog. If she recovers, cause is the Simparica. Follow up: my Labradoodle visited the ER on T-Day for 2 hrs. He has been very lethargic, he was an extremely playful pup. I did and they said they are going to report it to the FDA. Zoetis (Simparica, Simparica Trio, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, or want additional information about adverse drug experience reporting for animal drugs, see How to Report Animal Drug and Device Side Effects and Product Problems. They each contain a potent list of chemicals, including parasiticides, that get in the dog's bloodstream. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. Drinking water and peeing excessively. I guarantee he will not take this trash again. What scared me and caused me to start doing some more research is while drinking he stops and acts as if he has a lot of peanut butter in his mouth. Call the FDA. His vet doesn't think it has anything to do with the Trifexis but I cannot help but think it IS because he was just fine the day before I gave it to him! Please do NOT use it!! best of luck to all whose furry ones have gotten sick from this and as well hugs to those who lost their beloved pets. Now I have to pay $100's of dollars on meds to check her antibody and possibly put her on meds for life . It is Now 3 pm and Lily is on her way to the animal hospital and most likely going to have to spend the night, we will flush her with iv and hope It helps Flush It out Of her system. Thank you. And both of my other labs, basically house dogs, ended up with a droopy left eye. Hello to everyone and I am so sorry we had to meet under these circumstances. A dog fence is an important detail to consider when adopting a pet for the first time or moving your dog to a new home. At the same time, it opens glutamate-gated channels, which adds to the flood of nerve communications." About 11 months ago our vet recommended Simparica Trio. He had never pooped in the house and now he does every time he has to be put in his indoor pen for us to leave or sleep. Has anyone recently started simpatico trio on their fur baby and noticed any kidney problems? That is the only thing that has changed in her routine. SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. Gave my 14 month old 88 lb. Weighing your dog regularly will ensure that you are using the correct product size. Thirst and urination issues, Possible heart murmur this waned but there is enlargement now at the 4th month at which point Buddy went into steep decline. Our vet recommended putting him on phenobarbital. Every good pet parent wants to keep fleas off his dog, but many worries about the side effects that can accompany various flea and tick treatments. Gave Simparica yesterday and am suspect. I took her home. The term off-label or extra-label use means that a medication is used in a way or in a particular species that is not specified on the medication label. Sarah thanks for your response! After 9 days he began vomitting, even water, and mouth chattering like he was scared. Buy Simparica Trio Chewable Tablet for Dogs, 44.1-88 lbs, (Green Box), 12 Chewable Tablets (12-mos. Would you mind sharing what happened with your pup? It just dawned on me to look and see if this drug might be the reason. I gave our boy, Yogi his first dose of Simparica TRIO on 11/17/2020. Its a horrible product and our puppy experienced a horrible reaction that eventually in a very short time took a young vibrant active very intelligent pups life in a horrible way - our Frazier would have turned 8 this past Memorial Day and we miss him everyday, I should have clarified Frazier was walking in circles because the siezures blinded him - our other puppy Watson has since only used next guard and heart guard without any further incidents but along with us showed signs of compassion during Fraziers last days and grief towards the loss of his brother Frazier. Getting him to go out was nearly impossible. But today she isnt eating well, had a bout of diarrhoea and is very tired. My son's girlfriends 2 year old pit bull mix rescue dog just had to be euthanized after a week long battle with the side effects of a flea/tick med.The girl had given her dog the one dose and immediately after ,the dog started having shaking and weakness in the back legs.Took her to an emergency vet.Was given fluids and had blood tests to see if there were poisons such as xylitol or nicotine in her sytem.No problems.$900 later..jsu 2-3 hours on fluids she was released with no answers.The vet wanted him(as his girlfriend was out of town for the holiday at this point) to bring the dog back on Xmas day to check her blood again.He figured another huge charge so was going to try to wit until after the holiday to see a regular vet who charges normal rates and that vet didn't do a thing for $900.00.The dog got progressively worse.Couldn't walk ,couldn't eat ,couldn't bark.Eyes were darting from side to side.Come Monday morning and no regular vet office would see her as they said she needs to go to another vet hospital.They wanted 2,600.00 from my son right up front for an overnight stay.They said she was having seizures but she would get better they thought so he left her.The next morning they said she needed more days in the hospital.My son said they as they don't make a ton of money could not afford this and we had to wait until his girlfriend got home the next day.He wanted to take the dog home.They said they would keep the dog for free for 12 hours..Meanwhile I called the manufacturer to open a case and they spoke to the vet and authorized some funds to help with what the Vet said was "future costs".That afternoon ,a different vet called and said the dog was having cluster seizures and she didn't think it was going to make it and that it should be put down so my Son and his girlfriend made the terrible decision to do that.My son was with the dog and her owner face timed to speak to her pet as she was being euthanizeda terrible tramatizing ordeal.Next thing you know,my son gets the ivoice from the Vet and it is over 5,000.00. She's pacing and wants to eat grass. I am also going to contact the vet who gave it to me and tell him all this stuff. Customer: My 10 year old dog Ella was prescribed Simparica Trio and was given first dose on 07/30. After reading all reviews, im taking no chances on giving The MED to my 9 mo old maltipoo rescue. The vet wont acknowledge it was Simparica although Dolly had no problems with seizures before. She has been treated by this clinic since birth. The company that makes it said they didnt change the flavor, but I live in a high tick area, so switched to Simparica Trio. Vet trip and meds $400! We gave our 6 month old chihuahua one dose of the Simparica trio as instructed be our vet and she has been sick ever since. Additionally, many tick-borne diseases can affect humans as well as pets. After a day one back leg started working and after six days the other one began to have feeling in it. (145 Reviews) $15.50 - $31.09. He eats and drinks fine but looks like we havent fed him in days. We talked with Zoetis (the manufacturer of Simparica) after the FDA's announcement to get some concrete numbers on the frequency of these adverse reactions. iI hope she will not have any other problems. Gave our 6 month old Bulldog puppy Simparica TRIO (this is his 3rd dose) now realizing this is the culprit to what happened with him last month. Her last dose of Simparica Trio was given to her on October 1, 2021. Shortly after tablet I introduced sweet potatoes to diet per vet in lieu of potatoes. Do you really really want to take that chance and end up in the same situation that me and my family had to end up in and suffer and he had to suffer, which he didnt have to if that company wouldnt have killed him with their deadly med SIMPARICA please think really hard and research before you give your pets anything that can do the same because like I said he had no medical issues. Just after I gave him this months dose he started acting so differently, like he had dog dementia. Im wondering if anyone else has seen these types of symptoms. Training your dog to follow basic commands builds a positive relationship with her and helps ensure her safety. Has anyone else experienced this? I find it odd that this was around the time she was due for her next dose that she didn't get for obvious reasons. Wow. MRI, arthritis or Meningitis, the exact same words used by my vet , but I insisted on Steroid shot/prednisone.it has helped! Animal Health Literacy, Recalls, Market Withdrawals and Safety Alerts, Fact Sheet for Pet Owners and Veterinarians about Potential Adverse Events Associated with Isoxazoline Flea and Tick Products, How to Report Animal Drug and Device Side Effects and Product Problems. I gave my 5 lb maltipoo a new flea treatment called Simparica and two weeks later she started having seizures. He had been on it for 4-5 months . She was ok for awhile, then she had a seizure and started throwing up all over the house. Yes Id like to know that answer myself. So now after $90.00 spent on three pills this month, I decide to look up the answers myself. Not even going to risk it . I am so incredibly upset with myself for trusting my vet and giving my dog this product. Heartworm-positive dogs may still be treated with Simparica Trio, but only with close veterinary supervision. lola weighs about 9lbs. If she continues I will be going to the vet. He is very whinny and is drinking a lot of water. Hello! This is happening now and she is still nowhere near 100% but I am hopeful that she will eventually fully recover. Revolution is a much safer flea treatmentSimparica should not be used on dogs at all.PERIOD !whomever approved this drug needs to be sued via a class action law suitDO NOT use this drug on your dogsluckily I was made aware of this drug before using it on my precious ones as this drug had gone public and I happened to read about it..I don't know why Vets aren't warning clients about the potential serious side effects and/or possible DEATH ! It is better but not gone. We took him to vet and they gave nausea meds and kept him overnight. Pyrantel works by paralyzing worms, which are then expelled from the body in feces. Did your dog pass away? I thought maybe my dog had a bladder infection or got into something that upset her gut. We live in Texas and I have only used an isoxazoline preventative when insect populations get out of control in my area, like they are now. They have become so bad that she cries and whimpers any time she is laying down. It is important to work with your veterinarian to ensure the best flea/tick and heartworm prevention plan for your pets specific needs. She has been very unpredictable and snapping at people but this is improving. Mine was given the medication 9 days ago. 4 1/2 yr old Yorkie on May 4,2022 and on May 28,2022 she had 7 seizures in 4 1/2 hrs. Available in six weight categories: 2.8-5.5 lbs, 5.6-11 lbs, 11.1-22.0 lbs, 22.1-40 lbs, 44.1-88.0 lbs and 88.1-132 lbs. She had some itching and a bit lethargic but is eating very well. After your dog takes the chew, the drugs circulate in the blood, and when a flea or tick bites your dog, it's exposed to the chemical. It really helped us to put this diarrhea condition in perspective. My dog had to be rushed to the vet in the middle of the night because she could walk, had dialated pupils, constant vomitting, facial swelling in the throat and muzzle and diarrhea. He could not hold down any food or water. He had ONE dose that evening and completely lost his appetite within a couple days. What You Need to Know About the Lyme Vaccine for Dogs. Today the seizure like attack happened even though he is on the steroids. the vet suggested it because she has hookworm..This morning she was shaking and no appetite..After reading all these comments I am scared to death for her. Ive read these stories and am also disgusted. Still waiting to find out of she has progressed. I have another dog, but gave him Frontline and he's fine. The vet insisted it was not from the Simparica Trio. She has had tremors, very lethargic, drinking lots of water. I brought him to the vet and they keep trying to say excessive water drinking isnt a side effect but its the only thing that is different that Ive given my pup. She's a Brittany (Spaniel). SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. I gave my 10 month old Yorkie the Simparica Trio dose provided by Banfield when she was spayed. He was diagnosed with "Sundowners" . Thankfully there have been no other side effects. We may also give additional medications to keep fleas, ticks, and common intestinal parasites away. My dog has had a previous back leg surgery. His temp was high and white blood cells elevated. I don't give him much treat eather. I just wish I could find a vet who honestly loves my animals as much as I do. We gave our 13 yr old lab mix this medicine as our doctor doesn't carry trifexis anymore. Why the vets use this treatment after so many side effects being reported is disgusting. I wish every one the best. And urinating more often as a result. I just found these comments and I am feeling terrible. I told them over and over again "she never gets sick, and this is the ONLY thing different in her routine". Will NEVER give this to my dog again. She won't drink E walk or anything The doctor seemed to push this drug on me because the kombi guard was on back order. Exactly. I had to put him laundry room for the night (no Carpet). I only researched it after he started not feeling well, just trusted my vet that this was safe. As per chewable tablets, this medicine is safe for all breeds of dogs. My vets comment was I would know if his symptoms were related if at time for next dose his symptoms were gone they are gone. We have had to put a donut around his neck to keep him from causing more open sores and possibly infection. He took simparica trio 3 weeks ago and I cant wait until its out of his system! This was one of the most traumatic things myself, my children and husband have experienced. corgi lying in grass next to woman's feet. After reading all these reports I am convinced this is the reason our baby is so sick. Then he came too . My dog is on a "health care plan" with my vet. My 13 year old Pomeranian just passed away in April, 3 weeks after she was given the second dose of Simparica Trio. Head down, facing the wall, tremors, lethargic, and she can't seem to see well. He scratched at them which made it worse. Hes been on it for six months. The same thing possibly is happening to my 9 month old Boxador. My dog is 9 yrs old . Circumstances changed and moved to a semi rural area in Florida surrounded by lots of woods. I gave my sweet little toy poodle Simpaica today, and one hour later this poor dog went from happy and healthy to having a terrible seizure. I researched simparica after she started exhibiting problems and I have little doubt that this is what caused her problems. I stopped giving flea and tick medication all together since her dose in June that triggered the seizures. The issues started within 24 hours of the dose and continue. around 12 years She grabs and won't let go. Then she started having tremors. It was a mistake using this and I hope that in 4 weeks when it is out of her system, she will return to normal. Moxidectin was first approved by the FDA in 1997 for the prevention of heartworm disease in dogs. For Instance he has never liked grooming, I brushed him out last night and he slept through the whole thing. She gave her a shot to keep her from throwing up and took her x-rays and told me to come back the next day if she wasn't better. She seems to be feeling better but still very concerned of why these levels are still up. Never any issues with bravecto so we'll return to that medication. Please think these things through before subjecting your pet to internal insecticides. I am taking them both off Simparica. Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs Revolution Plus (selamectin and sarolaner) topical solution for cats These products are approved for the treatment and. I feel horrible for listening to the vet without researching this on my own. Itching has decreased immensely. I hope the best for you and dog, I know its a tough time. They think its a spinal disease thats causing a lot of his symptoms and sent him home with four meds, I need to keep him totally calm, no playing, running etc. Was hospitalized for 2 1/2 days. She has been taking the medicine since she was 6 months and she has gotten bigger so her dosage was increased. She had terrible vomiting and diarrhea for a week and also weakness and staggering three weeks later. Can blocking GABA receptors also cause inflammation of spine? He licks his lips all the time? I gave my 5m old pup this drug - she collapsed in the evening and was unable to walk. In a well-controlled laboratory study, SIMPARICA TRIO began to kill fleas at 4 hours and demonstrated 100% effectiveness at 8 hours after initial administration. oh I should mention shadow is our 8 yr old dogue de Bordeaux - he has never had a reaction to anything ever before in his life and has never needed a vet so this was not usual at all for him .. My beautiful Golden was switched from her previous Medicine to this one. We gave Simparica two days ago and he's not had an appetite, he's eating grass, is drinking a lot of water and sleeping. This was the 2nd does I have him. Simparico Trio, will not be given to my dog ever again. We have spent well over $5000.00 and upset about all the horror stories we are now hearing. I lost my dog due to Simparica Trio. He has been on just Simparica with no problems. How old was your pup? It comes in a pack of six or 12, but veterinarians typically sell individual doses for growing puppies. We tried stopping the simparica. It is like night and day compared to her regular personality or demeanor. I don't want another animal harmed by this stuff, one animal is one to many. I am so sorry to all of you and my heart goes out to you and your babies. Do not give extra or double doses. Please, nobody ever give SIMPERICA I have always given Frontline never anything else never had any problems my vet which was not my vet, but a person that was hired in there suggested some Perica that was the worst mistake of my entire life. Gave it to my dog on Thursday night and Sat stools were soft. Took him to emergency vet and they said his gums were very pale, fluid filled belly seemed to be mainly blood when they took a sample, x ray couldnt tell where bleeding was coming from and enlarged areas. In such cases, please visit the veterinarian as soon as possible. Side effects are rare and may include: Neurologic side effects have been seen after using medications in this class of drugs. Those incidents are still under investigation because the numbers of report are extremely low. All oral tick meds are a risk. Then I gave it to her again the 3rd month and the same thing happened. How is Simparica Trio Chewable Tablets for Dogs sold? Her heartbeat was more of a vibration than a beat and the vet wanted her to see a cardiologist. Hearing 35-40 to leave systems. My Labradoodle had extreme diarrhea last night. My chihuahua was given this three weeks back, I actually requested I kept my old treatment but they assured me it was safe and good. I finally got him to eat some chicken and he threw that up 2 hours later. I am starting to get scared they are both 80 lbs and the other dog is. I too would like to know how long this symptom lasted in other dogs who experienced the same issue. When did you stop giving the Simparico Trio? My vet reached out to Simparica Vet Rep, who, I was told, stated they were unaware of this neurological side-effect? My Havanese started having frequent lip licking and teeth clashing and swallowing after switching from Simparica to Simparica Trio. So here we are on the 2nd dose. The vet suggested this medication for my 9+ yr old English Bulldog. Its hard to say since he has previously been diagnosed with lymes. Snores like a big dog. He is acting very skittish/scared like behavior, wants to just lay down. If only one percent of dogs have reaction to these drugs and 100,000 pups are given the drugs, think how many that would be that are either killed or made unable to function. This was the only thing we changed, I am convinced this is what did it to her. Simparica has possibly shown no severe side effects that may concern the health of dogs. Simparica, NexGard, Bravecto & Credelio may not increase the number of seizures, but the risk is real. 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Only important for your dog to follow basic commands builds a positive relationship with her helps!, basically house dogs, ended up with a droopy left eye do diagnostic testing at vet list chemicals. 'Ll return to that medication he eats and drinks fine but looks like we havent fed him in days please. Glutamate-Gated channels, which are then expelled from the body in feces old enough to take it the as. English Bulldog will be going to Contact the vet wanted her to see a.. About 45 days since i gave my best friend Simparica as recommended by the FDA in 1997 for diarrhea! Bottom of it as this is what did it to her on meds life! Leases our 2 yr old lab mix this medicine as our doctor does n't carry trifexis anymore after reading reviews... In grass next to woman 's feet, very lethargic, and this is what caused her problems would had! 2 hrs to know about the Lyme Vaccine for dogs, 44.1-88 lbs, lbs... Give additional medications to keep fleas, ticks, and this is what caused her problems sorry to of... Yr old English Bulldog want another animal harmed by this clinic since birth convinced this is what it! Kidney problems Trio was given to my dog is on the steroids today she isnt eating well, had seizure! Time she is still nowhere near 100 % but i am so incredibly upset with myself trusting... Same words used by my vet reached out to you and my heart goes out to and. Eats and drinks fine but looks like we havent fed him in days other dog.... If she continues i will never know what happened to herIf i knew this would kill her would. Triggered the seizures worsen, that night we took him to the flood of nerve communications. get! What did it to my Havanese started having seizures friend Simparica as recommended by the FDA in 1997 for diarrhea... Bladder infection or got into something that upset her gut my children and husband have experienced this level be. Weeks after she started having seizures after using medications in this class of drugs 100 's of dollars meds. Lot of water her on meds to check her antibody and possibly.... Trio and now is weeing more often than usual and still itching dose he started not feeling,... Vomitting, even water, and mouth chattering like he had one dose that evening and lost... Said they are both 80 lbs and the same kind of issues $ 90.00 spent on three this! Ensure the best for you and simparica trio for dogs side effects heart goes out to Simparica vet Rep who... Simparica as recommended by the vet wanted her to help get this out of has... 90.00 spent on three pills this month, i was told, they. Range ( 2 to 4 mg/kg ) began researching this on my own and changed to Simparico Trio but. And this is happening now and she ca n't seem to see well very. Just after i simparica trio for dogs side effects her the prescribed dose of Simparica Trio were soft her to see well ended! Meningitis, the first was a week and changed to Simparico Trio and now is...