For treatment of mixed hyperlipidemia, Zetia is indicated to reduce total cholesterol, LDL cholesterol, non-HDL cholesterol, and ApoB. In clinical studies that lasted an average of 12 weeks, Zetia used with statin drugs was compared with a statin used with a placebo, and a statin used alone. For more information on possible side effects of Zetia, see the Zetia side effects section above. In the studies: Zetia is approved to treat the following conditions in children ages 10 years and older when used with a low-cholesterol diet: To learn more about how Zetia is used for these conditions, see the sections above. Cardiology 33 years experience. And Zetia hasnt been shown to affect blood sugar levels in clinical studies of people with diabetes and people without diabetes. The results showed that people taking statins reported decreased muscle-related symptoms after adding a CoQ10 supplement to their regimen. Talk with your doctor right away if you have fever or chills with your joint pain. It's Aimee Esther here! Fenofibrate is a drug used to lower your triglyceride levels. It can develop suddenly or maybe over time. The autonomic nervous system is in charge of all bodily functions that we don't have to think about, such as: The sympathetic nervous system is part of the autonomic nervous system. Symptoms of liver damage include: If you have any of the above symptoms of liver damage, tell your doctor right away. They may suggest foods that can help lower your cholesterol and reduce your risk of weight gain. Many rare diseases have limited information. A clinical study looked at children ages 10 to 17 years old with heterozygous familial hypercholesterolemia (HeFH). The autonomic nervous system controls systems like heart rate, blood pressure, digestion and temperature control, so people with dysautonomia may experience abnormal changes in blood pressure and heart rate, gastrointestinal issues, lightheadedness, fatigue, chest pain . Examples of statin drugs include atorvastatin (Lipitor) and simvastatin (Zocor). For more information and to find out if youre eligible for support, call 800-727-5400 or visit the program website. In rare cases, taking Zetia with a statin drug may cause rhabdomyolysis (muscle breakdown). Based on animal studies, Zetia may cause harm to the fetus when taken by a pregnant woman. Reverso Context ofer traducere n context din englez n romn pentru "but as in", cu exemple: Belgium overall has a good track record of achieving the nominal budgetary targets, but as in recent years a strict monitoring will be necessary to achieve the target for 2007. Talk with your doctor about any liver problems you may have and whether its safe for you to take Zetia. Doing this can raise your risk of side effects. Or they may recommend a product you apply to your skin, such as hydrocortisone cream. Using Zetia with medications in the fibrate drug class raises your risk of gallstones even more. If youve changed your diet since starting Zetia, this may be an explanation for any weight loss you may have had. Some people with POTS also may have one or more . This is because every persons body responds differently to medications. It is not yet clear what are the causes of POTS disease. Zones: Annual Height/Spread: 3 to 4 feet tall, 2 to 3 feet wide Exposure: Full sun Bloom Time: Spring to frost Color: Golden yellow (shown), deep red, orange, carmine rose, coral, lime, wine, purple, bright pink, white, salmon rose, and scarlet. Here's how ApoB tests can help doctors evaluate cholesterol levels and, in some cases, provide a better understanding of a, At-home testing can provide clarity about your cholesterol levels and risk of heart disease. Its FDA-approved to treat certain forms of high cholesterol in adults and in children ages 10 years and older. Total cholesterol is the overall amount of cholesterol found in your blood. Merck, the manufacturer of Zetia, offers a Patient Assistance Program. Study on Ezetimibe Yielded Disappointing Results: Another reader wrote us shortly after learning of the results of a study that raised questions about ezetimibe: Q. shortness of breath or troubled breathing. New evidence shows that the drug makers Merck and Schering-Plough have conducted several studies of their popular cholesterol medicine Zetia that raise questions about its risks to the liver, but . The following lists contain some of the key side effects that may occur while taking Zetia. Your body uses cholesterol to make some vitamins, hormones, and fluids that help you digest food. You may also want to check out the online communities at Bezzy. If you have liver problems, your liver may not work properly to remove medications such as Zetia from your body. Zetia can cause muscle-related side effects. upper respiratory tract infection, including the common cold. Postural orthostatic tachycardia syndrome (POTS) is a condition that causes a number of symptoms when you transition from lying down to standing up, such as a fast heart rate, dizziness and fatigue. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. Memory loss isnt a side effect of Zetia. Talk with your doctor if you have questions about managing your blood pressure or blood sugar while using Zetia. Cholesterol is made naturally in your liver. You can take Zetia with or without food. The only FDA-approved dosage of Zetia for children is 10 mg once a day. Note: Zetia isnt approved to lower these types of cholesterol: Cholesterol is measured in several ways. diarrhea. You may also have muscle cramps, spasms, or stiffness. Zetias effect on cardiovascular morbidity and mortality isnt known. You cannot reliably predict how your body will react to a treatment based on someone elses experience. Zetia is approved to treat certain forms of high cholesterol in children ages 10 years and older when used with a low-cholesterol diet. Taking Zetia with a statin may cause this side effect. POTS was also linked, to a lesser degree, to Covid vaccination with an mRNA vaccine, according to the new study. pain in your arms or legs. Your doctor will likely start you on the typical dosage approved to treat your condition. Other side effects not listed may also occur in some patients. As patients we need to be constantly wary because it is increasingly clear that the pharmas have abrogated their responsibility on our behalf. It belongs to a class of drugs called cholesterol absorption inhibitors. If you use Zetia and warfarin together, your doctor may want to monitor you more closely during your treatment. Most of these side effects may go away within a few days or a couple of weeks. Yes, treatment with Zetia should lower your triglycerides. For more information on these side effects, see Side effect details below. Additionally, a change in weight is not a listed side . The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. joint or muscle pain*. You can also ask your pharmacist for information on how to dispose of your medication. Symptoms of a swollen gallbladder may include: Tell your doctor if you experience gallstones while using Zetia with fenofibrate. * To learn more about this side effect, see the Side effects explained section below. Here are a few questions to get your discussion started with your doctor: To get information on different conditions and tips for improving your health, subscribe to any of Healthlines newsletters. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. The generic form of Zetia costs about the same as the generic form of Crestor. These drugs havent been directly compared in clinical studies. You may not have any symptoms of gallstones unless they cause your gallbladder to swell. The actual price youll pay depends on your insurance plan, your location, and the pharmacy you use. Here are some natural statins that may help keep your cholesterol in a healthy. Most patients will need at least 64 to 80 ounces (8 to 10 cups) of hydrating liquids throughout the day, such as water, broth, juice, or decaffeinated tea. I read that Zetia should be taken along with a diet low in cholesterol and saturated fat. For those who aren't familiar with POTS, it is an often-disabling neurological condition that causes your heart rate to rise a great deal when you are upright, and often blood pressure drops when you are upright (when it should be rising), and it causes fainting, fatigue, headache, nausea, face and hand tingling, and blood pooling in legs. Diarrhea is a common side effect of Zetia. These tests will look at your cholesterol levels and also your liver enzyme levels. More research is needed to know for sure. Specifically, Zetia is used along with a low-cholesterol diet to treat: Zetia is approved to treat these conditions in certain situations. These side effects may be temporary, lasting a few days to weeks. No, hair loss isnt a known side effect of Zetia. In these groups, joint pain occurred in: The length of time that adults and children experienced joint pain while taking Zetia in these clinical studies isnt known. Some people have mild symptoms, while for others it can have a big impact on their everyday lives. Primary hyperlipidemia is a genetic condition caused by a mutation (change) in the genes that control how cholesterol is cleared from your body. Last medically reviewed on September 18, 2021. Medications in this drug class prevent your liver from making new cholesterol. Zetia contains the active drug ezetimibe. They may also check you for signs of muscle breakdown or kidney damage. Instead, it belongs to a class of drugs called cholesterol absorption inhibitors. This causes less cholesterol to travel from your small intestine to your liver. Zetia can cause mild or serious side effects. Zetia (ezetimibe) is a prescription drug used to treat certain types of high cholesterol in adults and children. Lipitor contains the active drug atorvastatin. Also, Zetia use may cause increased liver enzyme levels, especially if its taken with a statin drug. Your doctor will determine the best dosage to fit your needs. However, your cholesterol levels may increase if you stop taking the drug. Currently, no medications have been approved by the FDA to treat POTS. For HoFH, Zetia is FDA-approved to decrease levels of total cholesterol and LDL cholesterol. If you have multiple health conditions, your doctor may recommend other medications for you to take with Zetia. Theyll likely have you stop taking Zetia and any statin drug you may be using. Medications in this drug class prevent your liver from making new cholesterol. The following information is provided for clinicians and other healthcare professionals. If the side effects seem life threatening or if you think youre having a medical emergency, immediately call 911 or your local emergency number. Call your doctor right away if you have serious side effects. They can both be taken with or without food. Here are answers to some frequently asked questions about Zetia. If you no longer need to take Zetia and have leftover medication, its important to dispose of it safely. This may increase your risk of side effects. Your doctor may do liver function tests before you start treatment and regularly during your Zetia treatment. Zetias side effects are usually mild, especially if youre taking Zetia alone. But new medications can help lower cholesterol and improve heart health. So stopping Zetia may lead to an increase in your cholesterol levels. They can suggest ways to help relieve your side effects, or they may recommend a different treatment option for you. Tell your doctor right away if you become pregnant while taking Zetia with a statin drug. unusual tiredness or weakness. Learn about the side effects it can cause and how to manage them. In Zetia's clinical studies, these were some of the side effects that occurred more often: pain in the arms or legs. stomach pain. The insurance company will review the prior authorization request and decide if the drug will be covered. The effect of Zetia, atorvastatin, or simvastatin on other types of cholesterol levels in this study isnt known. They can both be taken with or without food. If you drink alcohol, talk with your doctor about whether its safe for you to drink during your Zetia treatment. You may be able to find testimonials online from people who take Zetia. It can cause mild side effects and, less commonly, serious side effects. * Sex and gender exist on spectrums. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Like most drugs, Zetia can cause an allergic reaction in some people. This includes grapefruit and grapefruit juice. Learn about the common, mild, and serious side effects it can cause and how to manage them. POTS is a kind of dysautonomia or autonomic nervous disorder. Short term Zetia side effects include mild fatigue, dizziness, diarrhea, nausea and headache. This list contains examples of serious side effects that can occur with both Zetia and Crestor (when taken individually). Theyll likely suggest changes to your treatment plan. These problems can include muscle pain and muscle weakness, and rarely, muscle breakdown. Common side effects may include: diarrhea; cold symptoms such as stuffy nose, sneezing, sore throat; pain in an arm or leg; joint pain; or. Can diet help improve depression symptoms? Forget HDL and LDL. However, it isnt known how Zetia may affect these risks. zetia. This can cause Zetia to be less effective. Your doctor may prescribe Zetia with a statin drug. It isnt safe to eat grapefruit or drink grapefruit juice while using statins. So if youre taking Zetia with a statin drug, you may need to avoid eating grapefruit or drinking grapefruit juice during your treatment. See the Zetia prescribing information for details. You should always consult your doctor or another healthcare professional before taking any medication. Repatha is a prescription drug prescribed to lower LDL cholesterol and certain cardiovascular risks. However, excessive alcohol use can damage your liver over time. A generic drug is an exact copy of the active drug in a brand-name medication. For this purpose, Zetia may be used: The only FDA-approved dosage of Zetia is 10 mg once a day. This means you should avoid foods that are high in cholesterol and other types of fat. Here is a list of conditions that the Food and Drug Administration (FDA) has approved Zetia and Crestor to treat. Twelve weeks of treatment with Zetia and atorvastatin or simvastatin was compared with atorvastatin or simvastatin used alone. Get answers to some frequently asked questions about Zetias side effects. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Specific statins that were studied included atorvastatin (Lipitor), simvastatin (Zocor), pravastatin (Pravachol), and lovastatin. However, some people have reported experiencing memory loss when taking statin drugs. Zetia comes as a tablet that you swallow. In addition to Goff's specific symptoms, POTS can be associated with neurocognitive impairments or "brain fog"; problems with body temperature regulation; gastroenterological symptoms like nausea, abdominal pain, diarrhea, or constipation; and dark red-blue discoloration of the legs. To reduce your symptoms in . joint pain *. For more information, see Liver problems in the Precautions section below. If youre pregnant or breastfeeding, or if youre planning to become pregnant or breastfeed, tell your doctor. Learn more about the link. Your risk of developing serious side effects may increase if you take Zetia with other medications to treat high cholesterol, such as statin drugs. But over time, heavy alcohol use can damage your liver. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. To learn about other mild side effects, talk with your doctor or pharmacist, or view Zetias prescribing information. For more information about the effectiveness of Zetia for lowering your triglycerides, see the Zetia uses section above. Lying down on the bed, and raising your legs. Zetia does not cause an increase or a decrease in blood pressure. Clinical studies involved adults and children ages 10 years and older. Phase IV trials are used to detect adverse drug . If you develop serious side effects while taking Zetia, call your doctor right away. 5.8k views Answered >2 years ago. These drugs havent been directly compared in clinical studies. But its possible that some side effects may continue to affect you for as long as youre taking the medication. Taking Zetia with a statin drug may increase your risk of developing some mild or serious side effects. What is considered high cholesterol? Brand-name medications usually cost more than generics. Ezetimibe may cause side effects. If you miss a dose of Zetia, you can take your missed dose as soon as you remember. Serious side effects and their symptoms can include: * You may be more likely to experience this side effect if you take Zetia with a statin drug than if you take Zetia alone. Females who could become pregnant should use birth control while taking Zetia with a statin drug. Zetia can cause certain side effects, some of which are more common than others. If youve noticed memory problems while taking Zetia, talk with your doctor. voice changes. You likely wont notice Zetia working in your body. Theyll guide you with suggestions they may have to relieve these side effects. 1. Energy Drinks, such as Red Bull, should be avoided in those with POTS. Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. For this purpose, Zetia is used with a low-cholesterol diet (but with no other drugs) in adults and in children ages 10 years and older. And your doctor can use this information to adjust your treatment plan if needed. Symptoms can be mild or serious and can include: If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. Postural Tachycardia Syndrome (PoTS) is an abnormality of the autonomic nervous system (ANS). Bock's fainting spells are one of the hallmarks of POTS. Zetia generally costs more than Crestor. Zetia is also used to reduce blood levels of fats called plant sterols in people with homozygous sitosterolemia. Crestor is available in a generic form called rosuvastatin. Its not known if Zetia is safe to take during pregnancy. Medications in the fibrate drug class may increase the amount of cholesterol thats stored in your gallbladder. And generics tend to cost less than brand-name drugs. Have your doctor measure your heart rate sitting and standing. (A class of drugs is a group of medications that work in a similar way.) POTS is defined by its particular symptoms and an excessive increase in heart rate upon standing. Zetia is also available in a generic form called ezetimibe. If youre taking a statin drug with Zetia, they may recommend that you take a supplement called coenzyme Q10 (CoQ10). Brand-name medications usually cost more than generics. What are the serious side effects of Zetia? Crossing your legs in front of each other while standing, rocking up and down on your toes. Some drugs used to lower cholesterol can also decrease the risk of poor health and the risk of death associated with heart disease. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Also tell them about any vitamins, herbs, and supplements you use. An allergic reaction is possible after using Zetia. For more information, see the How Zetia works section below. Your doctor or pharmacist can help you choose one that doesnt have extra ingredients that you dont need. Zetia comes as a tablet that you swallow. Below are medications that can interact with Zetia. Theyll work with you to create a treatment plan based on scientific evidence and your unique health history. For more information on the possible side effects of Zetia, talk with your doctor or pharmacist. Our website services, content, and products are for informational purposes only. They can tell you about other medications that may work well for you. How long a medication remains good can depend on many factors, including how and where you store the medication. Note: Some of the drugs listed here are used off-label to treat these specific conditions. A decrease in the transport of intestinal cholesterol to the liver reduces stores of hepatic cholesterol. The manufacturer of Zetia hasnt stated whether the tablets can be crushed, split, or chewed. These include: Note: For more information about the potential negative effects of Zetia, see the Zetia side effects section above. Theyll guide you on the safest treatment options for you. Pots or postural tachycardia syndrome is, also known as postural orthostatic tachycardia syndrome, is a condition that affects the flow of blood in the heart and brain. As with most drugs, some people can have an allergic reaction after taking Zetia. A life-changing condition called POTS, which can cause fainting, irregular heartbeats and dizziness, particularly among young women, appears to be on the rise as a result of the coronavirus pandemic. Cholesterol absorption inhibitors prevent your small intestine from absorbing cholesterol. Welchol is a prescription drug used to treat type 2 diabetes and high cholesterol. There arent any foods that have been specifically reported to interact with Zetia. Statins are cholesterol drugs that may be taken with Zetia. If you feel dizzy from Zetia, it may help to take your dose at bedtime. Symptoms of atherosclerosis may include confusion, fatigue (lack of energy), trouble breathing, or pain in your chest, arms, or legs. To manage your symptoms, they may suggest an over-the-counter antihistamine you take by mouth, such as Benadryl (diphenhydramine). 4. The side effects from Zetia .. muscle weakness, joint pain, upper respiratory infectikns resemble the symptoms of malabsorption of Vitamin A,D, E and K. Our bodies need cholestorol to help coat our nerves and help with brain function and it naturally increases as we get older, so why are we trying to lower it, could this be why we are . If youre taking Zetia, talk with your doctor or pharmacist to see whether CoQ10 could be a good supplement for you. Zetia is a casebook example of the role the pharmaceutical industry increasingly chooses to play as it intervenes in human lives for corporate profit. Before approving coverage for Zetia, your insurance company may require you to get prior authorization. Drugs in this class prevent your small intestine from absorbing cholesterol. Weight gain isnt a side effect reported in clinical studies of Zetia. This helps prevent others, including children and pets, from taking the drug by accident. Learn about side effects, dosage, uses, interactions, and more. In the video she posted on Thursday, the "Real Housewives of New York City" alum detailed her suffering from a severe dehydration issue and shared that her doctor . However, you shouldnt stop taking Zetia without first talking with your doctor. These side effects may include diarrhea, muscle or joint aches, and cold symptoms, such as sore throat and congestion. Since every POTS patient is different, some may primarily experience gastrointestinal symptoms, such as nausea, vomiting or poor feeding, Berger explained. Less commonly, taking Zetia may lead to serious side effects. Zetia can interact with several other medications. Zetia is approvedto treat certain forms of high cholesterol in children ages 10 years and older. Below are examples of these side effects. And some may be easily managed, too. Once diagnosed, many patients face waiting lists as long as two years to get . High cholesterol may be caused by genetics, smoking, low amounts of physical activity, or eating too many high-cholesterol foods. Zetia may make warfarin (Coumadin, Jantoven) less effective at preventing blood clots. In addition, if ezetimibe is taken with a statin or fenofibrate, there may be an increased risk of . Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. In clinical studies, Zetia has been found to be effective for treating mixed high cholesterol when used with fenofibrate. Its also not known if the drug is safe to take while breastfeeding or whether the drug passes into breast milk. Both drugs are typically taken once each day. In clinical studies that lasted an average of 12 weeks, Zetia was compared with a placebo (a treatment with no active drug). Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia, or a malfunction of the autonomic nervous system. The side effects of Zetia in children are similar to the side effects in adults. Nausea/Vomiting. Postural orthostatic tachycardia syndrome (POTS) is a blood circulation disorder characterized by two factors: A specific group of symptoms that frequently occur when standing upright. These lists dont include all possible side effects. Zetia is primarily cleared from the body through fecal excretion. They can tell you whether the supplement may interact with any medications youre taking. Cholesterol itself isnt a harmful substance. Youll likely take Zetia once a day. Avoid eating foods high in fat or cholesterol, or Zetia will not be as effective. Zetia is meant to be used as a long-term treatment. If you have any questions about eating certain foods while taking Zetia, talk with your doctor. Muscle problems were reported in clinical studies of adults and children who took Zetia with statin drugs. But the condition isn't well understood, and many patients are dismissed as having anxiety, delaying diagnosis. Statins are another type of medication used to lower cholesterol. If you have kidney problems, you may experience even higher levels of Zetia in your body. In studies, some people had to stop taking Zetia because of this side effect. LDL cholesterol was reduced by 15% more in children who took Zetia and simvastatin than in children who took simvastatin alone. Zetias mechanism of action is considered complementary to that of statins and fenofibrate. If your doctor confirms you had a serious allergic reaction to Zetia, they may have you switch to a different treatment. Lipitor is an HMG-CoA reductase inhibitor (a "statin" drug) and Zetia is a cholesterol -lowering drug. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. Zetia may not be right for you if you have certain medical conditions or other factors that affect your health. Postural orthostatic tachycardia syndrome (POTS) is a condition characterized by lightheadedness or dizziness when standing and a racing heart. Here is a list of conditions that the Food and Drug Administration (FDA) has approved Zetia and Lipitor to treat. Different interactions can cause different effects. It also helps keep the drug from harming the environment. It belongs to a class of drugs called cholesterol absorption inhibitors. This date is typically 1 year from the date they dispensed the medication. No, stopping Zetia shouldnt cause any side effects. Youll also need to check your insurance plan, as it may only cover one or the other. In clinical studies of Zetia used with statin drugs to treat primary hyperlipidemia in adults and in children ages 10 years and older: It isnt known how long adults and children experienced muscle pain while taking Zetia with statin drugs in these clinical studies. However, you may still experience muscle problems if you use Zetia alone. Zetia contains the active drug ezetimibe. Your FAQs Answered: Life Expectancy and Familial Hypercholesterolemia, Inherited High Cholesterol and Heart Disease: What to Ask Your Doctor, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Heart Disease: How ApoB Cholesterol Tests Can More Accurately Identify Risks, Treatments, The 5 Best At-Home Cholesterol Tests in 2023, African Americans, Cholesterol, and the Risk of Heart Disease, Heart Health Breakthroughs: Top Advancements and Innovations of 2022, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your mouth, tongue, or throat, which can make it hard to breathe, what dose of drug you were taking when you had the side effect, how soon after starting that dose you had the side effect, what your symptoms were from the side effect, what other medications you were also taking, any other information you feel is important, taking other medications, especially high dose statin drugs. 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